Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports
نویسندگان
چکیده
منابع مشابه
Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports.
Contributors: HTOD and TGR designed the study; C-LH collected the data and did the analysis; HTOD led on writing the paper, with substantial contributions from TGR and C-LH. HTOD acts as guarantor. Funding: Nuffield Trust, London, and the Commonwealth Fund, New York. The guarantor accepts full responsibility for the conduct of the study, had access to the data, and controlled the decision to pu...
متن کاملPlasmodium falciparum Malaria and Atovaquone-Proguanil Treatment Failure
We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum-infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability. The follow-up of such patients should be strengthened.
متن کاملAtovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.
Thirty-eight of 295 subjects participating in a randomized, double-blind, placebo-controlled trial of the efficacy of daily administration of atovaquone/proguanil for malaria prevention developed malaria at some time during the 20-week prophylaxis period. These subjects (3 atovaquone/proguanil recipients and 35 placebo recipients) were treated with 4 tablets of atovaquone/proguanil per day for ...
متن کاملEfficacy and safety of atovaquone/proguanil as suppressive prophylaxis for Plasmodium falciparum malaria.
Currently recommended prophylactic regimens for Plasmodium falciparum malaria are associated with a high incidence of adverse events and/or suboptimal efficacy. In a double-blind, placebo-controlled, randomized clinical trial in western Kenya, adult volunteers received a treatment course of atovaquone/proguanil hydrochloride (250 mg/100 mg per tablet) to eliminate preexisting infection. Immedia...
متن کاملRandomized trial of artesunate-amodiaquine, atovaquone-proguanil, and artesunate-atovaquone-proguanil for the treatment of uncomplicated falciparum malaria in children.
BACKGROUND Artemisinin-based combination therapies (ACTs) are recommended for the treatment of acute uncomplicated falciparum malaria in many malaria-endemic countries. Despite the emergence of artemisinin resistance, few alternative non-ACTs, including atovaquone-proguanil, are currently available. METHODS Plasmodium falciparum-infected Cameroonian children ≤5 years old (n = 338) were random...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 2003
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.326.7390.628